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However, as reflected in the literature [ 18] the effect on sleep and activities are key markers of symptom severity.
The study team conceptualized that one or more markers of symptom severity could be so interrelated to symptoms that they might scale together with symptoms.
This qualitative research identifies a set of symptoms and markers of symptom severity that are relevant to the experience of patients who have asthma.
Therefore a decision was made that, if supported by patient qualitative research, these two items would be retained (at least in the qualitative phase of study) as markers of symptom severity.
Clinicians tend to underestimate asthma symptom severity, making the use of a patient-completed daily diary for the assessment of asthma symptoms and markers of symptom severity in clinical trials essential [ 11- 13].
Night awakenings and activity limitations (considered symptom-related clinical manifestations by GINA, also referred to as markers of symptom severity) were the two most frequently reported impacts among both adolescents and adults and these were retained as well.
Similar(46)
However, rescue salbutamol on an as-needed basis for breakthrough symptoms provided a secondary marker of symptom control.
Thus, by analogy with asthma, reliever use in COPD may be a sensitive marker of symptom variability [ 14] and of the extent to which an intervention improves symptom control.
In fact, considering that amygdala enlargement could be a marker of symptoms remission, remitted subjects are progressively excluded from the study because they show fewer symptoms.
The study was designed to characterize the symptom experience of people with HIV/AIDS and to identify biological and genetic markers of the symptom experience.
Although our analyses focused on potential inflammatory markers of subsyndromal symptoms in BD-I, no actual associations were presented between inflammatory markers and specific symptoms.
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