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Snail is also required for the expression of putative markers of stem cells, such as aldehyde dehydrogenase 1 (ALDH1; [ 12]), and can induce the expression of stemness-promoting genes, such as Nanog, KLF4, and TCF-4 [ 13].
Previous studies have reported that cardiac explant derived cells express markers of stem cells[1], [2].
Both COUP-TFII and RORα are among 426 selected markers of stem cells described [ 30].
We wanted to characterize the expression of putative markers of stem cells in the early phases of colon carcinogenesis.
They expressed mRNAs for the NANOG, OCT4 and BMI1 genes which are molecular markers of stem cells/progenitors.
Several CK's have been proposed as markers of stem cells, transient amplifying cells or differentiated cells [ 5, 7, 14].
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Although markers of stem-like cells are debated in the field, many groups agree that high expression of aldehyde dehydrogenase is a strong indicator of stem-like characteristics (Huang et al, 2009).
It has become a high priority to find a molecule (preferably one functionally involved in determining stemness) that is a specific marker of stem cell function, for their evaluation during normal and pathogenic development.
It is further revealed by gene expression analysis that cells proliferated in the EGF-incorporating collagen hydrogel contained subpopulations expressing the marker of stem cells, neurons, astrocytes, or oligodendrocytes.
MS analysis revealed that 2,3-sialylated glycans, a potential marker of stem cell function, were more abundant on hMSCs expanded on FN-coated surface than on those expanded on PS-MBP-FGF2.
These data together with other data presented below, lead us to conclude that CD133 is probably not a specific marker of stem cells in CRC.
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