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These included osterix and Runx2 of the osteogenic pathway (Fig 1B), the key adipogenic transcription factors PPARγ and CCAAT/enhancer binding protein α (CEBPα) (Fig 1C), early markers of skeletal muscle differentiation and cardiac transcription factors (Fig 1D).
Since the levels of late differentiation markers of skeletal myogenesis (e.g. myogenin and Myosin heavy chain) were not elevated even upon induction of MEFs towards the skeletal muscle lineage using horse serum and insulin, we adopted the skeletal muscle committed cell-line C2 [49] as the most suitable in vitro system to study the role of p53 during myogenesis.
The effect of corticosteroid on biochemical markers of skeletal turnover can be varied according to a number of biases.
Clinical chemistry provides markers of skeletal metabolism that can be used for monitoring or to complement other diagnostic modalities.
These functions may make IGF-1 and its binding proteins good markers of skeletal muscle molecular changes and useful for understanding the peripheral effects of heart failure.
In summary, we did not find evidence of benefits on surrogate markers of skeletal health from vitamin D supplementation in patients with sarcoidosis and vitamin D insufficiency.
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Blood lactate measurements are common as a marker of skeletal muscle metabolism in sport medicine.
Therefore, expression of these genes is now served as an early marker of skeletal muscle atrophy.
Plasma 3-methylhistidine levels, a marker of skeletal muscle protein degradation, were similar across all groups (Table 2).
Serum creatinine is a possible surrogate marker of skeletal muscle mass.
7 8 Sorichter et al 9 described the features of an ideal marker of skeletal muscle fibre injury.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com