From the enlarged set: EFNA1, EIF2AK2, FAM38A, MED1, MGEF8, PPL, SCARA3, SMO, and ZFHX4), several of these genes could be potential markers of radiation-induced thyroid tumors, independently of the histology and the internal external type of radiation exposure.
Here, we survey DNA DSB induction and repair in whole cells from RS patients, as revealed by γH2AX foci assays, as potential predictive markers of clinical radiation response.
Research should focus on identifying molecular markers for radiation sensitivity while designing specific, targeted modulators of the radiation response in early breast cancer.
Stereotactic radiation by using fiducial markers permits higher doses of radiation while reducing the exposure of uninvolved, adjacent structures.
We believe that the 77 identified peaks discriminating irradiated from nonirradiated tumours may include useful markers for the efficacy of radiation treatment of malignant glioma.
This association may represent initial evidence that telangiectasiae can be used as a marker of future radiation-induced cardiac complications.
The use of SPECT computed tomography rather than planar SPECT improves detection of tracer deposition in the gallbladder [ 31] and might therefore serve as a marker for increased risk of radiation cholecystitis.
To summarise, the data presented here support the hypothesis that at least some breast cancer patients, who develop severe reactions to radiotherapy, have an intrinsic radiosensitivity that can be identified in peripheral blood lymphocytes by quantifying gene expression response to IR and that CDKN1A is a surrogate marker for early effects of radiation therapy.
It is unclear whether the chromosomal abnormalities in the tumours from Gomel are important in their pathogenesis or merely markers of genomic susceptibility to radiation damage.
