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Immuno-epidemiological studies of people living in malaria-endemic areas have not produced consistent examples of surrogate markers of protection.
The use of immunological surrogate markers of protection is a practical way to monitor the duration of protection.
The immunological markers of protection against TB have not yet been defined.
Antigens predominantly expressed by dormant M. tuberculosis during LTBI are promising candidate immune markers of protection [5].
In addition, the lack of surrogate markers of protection renders the vaccine discovery process difficult and time consuming.
More reliable markers of protection would accelerate the development of novel and more effective vaccination strategies against human and bovine tuberculosis.
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The AR is a surrogate marker of protection against infection.
So, in light of published data and our results, IgG3 against Erp could be used as a surrogate marker of protection against TB.
Limitations include possible recall bias of vaccination status (retrospectively collected information) and the fact that antibody response is a surrogate marker of protection.
Significant associations with protection against GE were found for post dose 3 titers of RV-IgA in vaccinees, however, no specific titer could be identified as a marker of protection for RRV-TV vaccine.
The cut-off of the assay was a dilution titre of 1 8, which is considered a surrogate marker of protection for rSBA-MenC [ 9] and has been extended to the other serogroups [ 12].
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