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Using surrogate markers of progression can shorten the duration of clinical trials in progressive MS. ¹H-magnetic resonance spectroscopy (¹H-MRS) of the brain in MS patients can detect changes in cell metabolites in both focal lesions and normal-appearing white matter (NAWM) [ 4].
We found image-based evidence that some in situ mammary cancers did not progress to invasive cancers, and investigated potential predictive markers of progression.
The molecular changes associated with hormone‐ and vitamin‐driven responses and the deregulation of the expression and function of their target genes seem to correlate with specific biological events linked with cancer invasion and progression, and these findings could lead to the establishment of new markers of progression and to the development of new strategies for patient management.
as putative predictive markers of progression to DSS.
These cytokines are also markers of progression of a tuberculosis infection to active disease status [8].
Characterization of these genomic abnormalities in prostate cancer may therefore help to understand the molecular pathogenesis and may unveil genetic markers of progression.
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The switch in TGFβ responses from growth-suppressive to EMT-inducing involves a change from Smad-dependent to Smad-independent signaling [24] and appears to be a critical marker of progression in HPV-mediated HNC and EMT.
If there is such a relationship, virus expression and mutation could be a marker of progression, perhaps a manifestation of lymphocyte activation [33].
TRAP might be useful as a marker of progression of malignant disease.
We also wanted to investigate p53 immunoreactivity as a marker of progression to invasion.
MMP1 has also been proposed as a marker of progression into BRC [ 61].
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