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Some senescent cells form distinctive heterochromatic foci (SAHFs) [9], [10], and many harbor markers of persistent DNA damage [2], [11], [12], [13], [14].
Although our findings require replication in larger independent prospective asthma cohorts, the data suggest that prognostic DNA methylation markers of persistent asthma may be identified.
Metabolic acidosis and lactic acidosis are byproducts of anaerobic metabolism, and when they are measured in serum they can be useful markers of persistent tissue hypoxia or oxygen debt.
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Strength-duration time constant (SDTC) provides a surrogate marker of persistent Na+ conductances active at threshold [23], [24], while refractoriness classically relates to inactivation of transient Na+ channels [27], [29].
Strength-duration time constant (SDTC) and rheobase were determined according to Weiss Laww, utilising the relationship between stimulus charge and stimulus duration [22], [23], as a marker of persistent Na+ channel activity [24].
Calcitonin is a highly sensitive marker of persistent disease that is more sensitive than any other imaging modality (Frank-Raue et al, 1992; Abdelmoumene et al, 1994).
This is the first study to identify low sclerostin serum levels as a possible marker of persistent inflammation in AS patients under anti-TNF therapy.
Developing preoperative noninvasive imaging prognostic markers of postoperative seizure outcome is an important research objective, particularly as patient counselling and treatment management could be informed by the identification of a prospective marker of persistent, or even worsening, postoperative seizures.
The persistence of these short lived [ 4] specific IgA antibodies may be a marker of persistent infection [ 5], and has been used in the definition of chronic Cpn infection [ 6- 10].
In this line, NRP2 expression could be used as marker of persistent TGF-β activity in HCC patients which is indicative of HCC progression via the tumor promoting arm of TGF-β [ 38, 39].
As thyroid cells are assumed to be the only source of thyroglobulin (Tg) in the human body, circulating Tg serves as a biochemical marker of persistent or recurrent disease in DTC follow-up.
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