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A generalised boosted regression model identified markers of particular interest.
Raman spectral features can be used as identification markers of particular substances because complex molecules have several specific vibrational energy modes allowing the Raman spectrum of each substance to be highly specific and distinctive [ 3]. Figure 2 shows an example of a Raman spectrum recorded from a cervical cancer cell line, CaSki.
The disadvantage of the bin mapping approach is that there is a loss of precision in marker location (8 25 cM), but this can be solved for markers of particular interest by running the whole population to establish a more precise position or narrow down a region where closely related genes or common RFLP markers in apple has been fine mapped.
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β-catenin is a marker of particular interest here; depending on its localization in the cell, it is either a structural epithelial marker or a mesenchymal functional marker.
For example, the ErbB2 amplification is a well-known marker of particular forms of breast cancer that are treatable by the drug trastuzumab.
A second goal was to establish whether ageing of the periorbital skin could be used as an objective marker of particular patterns of sun exposure and ultimately therefore of risk of skin cancers.
As to why observational estimates may indicate a beneficial effect of l-ascorbic acid, L-ascorbic acid may be a marker of particular foods and lifestyles, which are genuine risk factors for disease (18 , 20 35, 36).
Molecular markers based on DNA methylation, that is methylation markers, are of particular interest as recent studies indicate that DNA methylation can be easily detected in cervical scrapes using sensitive PCR-based methods like methylation-specific PCR (MSP).
Molecular markers are of particular utility when applied to small, morphologically conserved taxa, as is the case for many monogenean ectoparasites of fish.
We examined several other markers and of particular interest was Jagged-1, a single pass transmembrane Notch ligand in vertebrates [29].
These features of DArT markers are of particular importance in the presented research, since most of the rye accessions analyzed are likely to be highly heterozygous and heterogeneous and to vary in allelic frequencies for a number of markers.
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