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This panel contains potentially more stable and sensitive markers of modulation of low-grade inflammation in overweight subjects, as compared to the established markers that often also respond to an acute inflammatory challenge.
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Furthermore, it should be noted that additional studies are needed to determine whether the markers identified here are specific for modulation of inflammation through inhibition of prostaglandin synthesis or if they are more general markers of inflammatory modulation.
The markers in the network may each be sensitive markers of inflammatory modulation.
The role of aging on markers of autonomic modulation at rest or during exercise is well established.
Novel candidate markers of inflammatory modulation included PBMC expression of annexin A1 and caspase 8, and the arachidonic acid metabolite 5,6-DHET.
A primary goal of this study was to identify markers for modulation of inflammation in reponse to diclofenac intervention.
HRV measures provide information primarily on vagal modulation with the LF power spectrum reflecting both sympathetic and parasympathetic modulation and HF acting as a surrogate marker of parasympathetic modulation of the R-R intervals [ 12].
It can be considered a marker of sympathetic modulation or a parameter including both sympathetic and vagal influences.
We observed the largest difference with adjustment for RMSSD (RR = 1.03; 95% CI, 1.0 1.05), a marker of parasympathetic modulation.
γH2AX induction in combinations containing gemcitabine or camptothecin could potentially serve as a predictive marker of pathway modulation and therapeutic outcome.
HF power reflects vagal and respiratory mediated changes in heart rate, whereas LF power is mostly a marker of sympathetic modulation [ 13].
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