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Low self-perceived health, depressed mood and high level of somatic complaints were chosen as markers of internal stressors.
This approach must be based on a clear theoretical framework that incorporates measurement and modeling of external exposure, databanks on patterns of behaviors, and markers of internal exposure.
We describe two collaborative studies on tobacco smoking, in which markers of internal dose (arylamine-hemoglobin adducts) and markers of genetically-based metabolic polymorphism have been coupled.
Manual quantifications were also performed for co-localization event between Jen1-GFP with markers of internal compartments (Sec7-mCh and Vps17-mCh).
A chapter entitled 'Skin markers of internal malignancy' confirms the suspicion that this book is highly oriented towards dermatologists rather than oncologists.
Additional studies of the genotoxic and hematologic effects of formaldehyde exposure in occupational cohorts and in experimental animals would be useful, and such studies should incorporate sensitive biological markers of internal dose.
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Event-related potential associated with error processing (error-related negativity – ERN) is considered a marker of internal and external feedback for processing conflict information.
When confirmed in larger cohorts, these data may suggest a helpful role of this simple counting score as marker of internal organ involvement.
However, the alpha-coefficients are a marker of internal consistency, which is one indicator of reliability.
While serum PCB concentrations serve as a marker of internal dose, CYP1A2 activity indicates an early biological effect of such exposure, at least among those persons genetically predisposed.
In the earlier investigations (Fitzgerald et al. 1996, 1999, 2004), we used serum PCB concentrations as a marker of internal dose, whereas in this study we expanded the focus to include a measure of an early biological effect of exposure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com