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VZV-specific CD4+ T cells expressed markers of intermediate differentiation and activation.
Markers of intermediate stages of differentiation (O1 and CNP, Figure 6C and Figure S2) were reduced at later time points but also remained suppressed throughout the observation period (up to 7 years).
Biological markers of intermediate health outcomes sometimes provide a superior alternative to traditional measures of pollutant-related disease.
For markers of intermediate health outcomes, the most important property is the positive predictive value for clinical outcomes of interest.
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Thus, this gene could be a marker of intermediate grade GVHR.
A minor proportion (≈20%) express high levels of the chondroitin sulphate proteoglycan NG2, a marker of intermediate and late OPCs and early pre-oligodendrocytes [40], and the majority of these cells co-express PDGFRα, indicating overlap of these two markers in hNSC-derived OPCs.
The expression of K19 was used as a marker of intermediate differentiated cells, and the expression of K8 was used as a marker of luminal epithelia (21, 22).
Smad3 co-localizes with Mash1, a specific marker of intermediate progenitor cells, and its expression persists in neuroblasts, immature and mature neurons.
Consistent with a role for iASPP in suppressing epithelial differentiation, we observed an increase in the expression level of Ck19, a marker of intermediate prostate epithelial cells, in iASPPΔ8/Δ8 mouse prostates.
However, it has been reported that activation of Notch signaling in keratinocytes is sufficient to cause cell cycle withdrawal, through induction of p21WAF1/Cip1 and expression of terminal differentiation markers of the intermediate epidermal layers [21].
Two other proteins that appear in all of our cell populations (except hOST) may also serve as markers of an intermediate state: glucose phosphate isomerase (also known as Autocrine Motility Factor) regulates cell growth and migration of numerous cell types [ 39], and activin A receptor (type IIB) supports growth of germ cells in the developing human embryo [ 40].
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