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Although we did not measure markers of hemolysis, visual inspection of the samples did not suggest hemolysis.
We have also shown that markers of hemolysis are a disease component forecasting earlier death using network modeling [40].
Tricuspid regurgitation velocity (which reflects systolic pulmonary artery pressure), mitral valve E/Edti ratio (which reflects left ventricular diastolic dysfunction), and a hemolytic component derived from four markers of hemolysis and hemoglobin oxygen saturation were also determined.
Priapism and leg ulcers are also associated with markers of hemolysis leading to speculation that these, and perhaps other disease manifestations, like stroke, could also be a consequence of hemolysis-induced NO deficiency [4], [7] [9].
Changes in markers of hemolysis (hemoglobin, reticulocytes, lactate dehydrogenase (LDH), and bilirubin) hypercoagulability, endothelial activation, and inflammation, and tolerability of oral NAC were secondary end points.
These observations have now been corroborated in children with malaria showing that neutrophil dysfunction was associated with parasite biomass and markers of hemolysis [ 17].
Similar(45)
In this process, we found that, in addition to a composite marker of hemolysis, circulating angiogenic and inflammatory markers were associated with elevated tricuspid regurgitation velocity but not with elevated mitral valve E/Etdi ratio in children and adolescents with sickle cell disease.
We reasoned that a marker of hemolysis such as haptoglobin could discriminate respiratory distress caused by pneumonia from that caused by severe malaria because haptoglobin levels increase with pneumonia severity and decrease with malaria severity owing to erythrocyte destruction.
In AIHA haptoglobin represents the most sensitive marker of hemolysis and it is the last one to normalize after recovery, possibly remaining decreased even in the presence of normal Hb levels (personal observation).
In a 12-week, multicenter, phase 2, randomized, double-blind, dose-finding study, we evaluated senicapoc's safety and its effect on hemoglobin level and markers of RBC hemolysis in sickle cell anemia patients.
Moreover, other markers of intravascular hemolysis such as haptoglobin or LDH were not available for analysis.
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