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Metabolite concentrations represent sensitive markers of genomic changes and responses of cells and tissues to external stimuli [4] [9].
Following this work, Monot et al [19] compared the stability of two different markers of genomic biodiversity of M. leprae in several biopsy samples isolated from the same leprosy patient (VNTRs and SNPs).
In citrus, the number of published markers of genomic SSRs is still limited [ 11, 12].
We have examined effects of this supplement on markers of genomic stability.
However, Okada et al. (2010) observed an SD of only 9% for the single dose markers of genomic and eSSR markers.
Whilst the majority of biomarker candidates are protein markers developed using IHC, markers of genomic instability using more quantitative techniques have shown excellent prognostic capability.
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Micronuclei (MN) frequency in lymphocytes is a marker of genomic damage and can predict adult cancer risk.
Because most of colorectal cancers with stable microsatellites demonstrate chromosomal instability [ 35], CDK1SA may have value as a marker of genomic instability.
The MN test, widely accepted for in vitro and in vivo genotoxicity research, provides a sensitive marker of genomic damage associated to diverse conditions.
Methylation levels are also probably to differ between cancer DNA and leukocyte DNA; therefore, the use of peripheral leukocyte DNA methylation as a surrogate marker of genomic instability in target tumor tissue should be evaluated in further studies.
The final markers of these genomic changes (amyloid-β1-42 and total τ levels) were verified by proteomic determination.
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