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To answer these questions will require markers of general chemosensitivity and drug-specific chemosensitivity, respectively.
The absence of FGF21 strongly impaired the capacity of GW9508 to induce BAT thermogenic activation, as evidenced by decreased induction of thermogenic genes (for example, UCP1, PGC-1α and Bmp8b) and Glut1, whereas markers of general adipogenesis (for example, FABP4) were unaltered (Fig. 9a).
At baseline, and at designated time points during the 8-week study, asthma control, symptoms, and Quality of Life questionnaires (ACQ, ASUI, mini-AQLQ) were assessed and blood was collected for analyses of markers of general health, oxidative stress, and inflammation.
Interestingly, lactate levels exhibit a stronger correlation with the number of inflammatory plaques than with markers of general CNS inflammation (IgG levels, oligoclonality).
These risk items may be markers of general dysfunction underpinned by cognitive impairment.
More biological markers of general nature, such as blood status, were collected for overall health matters or all-purpose profiling.
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Serum albumin levels are generally considered as a practical marker of general health or of nutritional status [ 24].
Because vitamin D is an excellent marker of general health status, the positive results reported in some observational studies might reflect unmeasured and unaccounted confounding.
When Steven Devor and his colleagues at Ohio State University assigned 54 men and women to a five-day-a-week crossfit programme for ten weeks, they saw big improvements in participants' aerobic capacity (a marker of general fitness), a 3-43-4%ll in fat and increases in muscle, regardless of initial level of fitness.
Change in the expression of six genes namely autolysin like genes AtlE (N-acetylmuramoyl-l-alanine amidase type), and AtlA like genes, Polyribonucleotide nucleotidyl transferase as a marker of general stress (PnpA), superoxide dismutase gene (SOD), ymcA and gtfB genes was studied to check the cell death, general stress and biofilm formation activities.
Interestingly, oligoclonality, which is a marker of general CNS inflammation and present in 79 90% of MS patients, was less correlated with the number of inflammatory plaques than were lactate levels.
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