Furthermore, using a larger population of mice with an increased number suffering severe injury, there no difference in the 21 day kidney-to-body-weight ratio (a surrogate marker of extent of scarring) as a function of severity of initial injury between the WT and Clic4 nulls.
Our results suggest that changes in salivary flow and composition as well as dental caries may serve as potential markers of the extent of autoimmune-mediated salivary gland dysfunction in pSS.
Unless we succeed in the prequel of building a composite prognostic index, including an increasing number of factors and inclusive biomarkers, 'we might consider the TNM method for lung cancer staging to be similar to 'brownstone' remnants of historical interest and accept biological markers of disease extent and behaviour as the skyscrapers of our future' [71].
The hypotheses generated from our results on changes in salivary flow and composition as well as high caries experience as potential markers of the extent of autoimmune-mediated salivary gland dysfunction in pSS therefore need to be tested in a large prospective cohort study including patients with early to long-standing disease.
When we evaluated all the measures available following prostate biopsy, we found that markers of tumour extent could accurately identify men who should not receive focal prostate ablation, but we were unable to identify reliably those men with solitary lesions who would benefit from focal therapy.
Yet, to date, there has been limited evaluation of this technology's newly available combination of wound infection parameters as diagnostic markers for extent of disease (17, 19– 219.
RFR may be a reliable marker of the extent of "recruitable" GFR under renal stress.
We chose to enter the variable depicting number of lymph nodes dissected, as we felt this is a better marker of the extent of surgical intervention undertaken at HVCs and TFs compared to LVCs and NTFs.
TH was chosen as a marker of the extent of the dopamine depletion, whereas CalDAG-GEFII and MOR1 are two immunomarkers that have been previously shown to be dysregulated by combined 6-OHDA lesion and L-DOPA therapy [9], [41].
To assess the diagnostic role of circulating TM as a marker of the extent and severity of coronary arterial atherosclerosis.
