In the process of obtaining a driver's license, a healthy 28 year old man presented increased levels of disialo-transferrin (TF) (approx. 20%, ref. value < 2) by HPLC analysis of TF isoforms (%CDT), while other markers of excessive alcohol consumption (PEth, MCV and γ-GT) were in the normal range.
It may be that consumption of fats and sugar, which are likely to contribute to high levels of overweight and obesity, could be interpreted as markers of excessive body weight.
This study evaluates the usefulness of erythrocyte creatine as a sensitive marker of excessive erythrocyte destruction due to hypersplenism in patients with liver cirrhosis.
Longitudinal studies, with several time points and a larger representation of varying disease severity would enable a better description of NE-degraded elastin as a marker of excessive ECM lung turnover.
In agreement with such thesis are also our previous results showing an increased lipid saturation (a marker of excessive oxidative stress) and conformational changes of proteins in the DG and CA3 hippocampal areas from animals treated with pilocarpine [ 11].
By adjusting by CRP, a proinflammatory biomarker, we controlled for the confounder effect of inflammation, and thus, the association between ferritin levels, as a marker of excessive body iron stores, and the metabolic syndrome was strengthened.
The presence of the soluble fragment of this molecule may represent either an adaptive excess of the protective molecule on an essentially healthy endothelium, or be a marker of excessive endothelial damage if also accompanied by high levels of other markers such sICAM (Wu et al., 2003).
Serum GGT has long been used as a liver function test and a marker of excessive alcohol use; [ 36, 37] about 35% of women and 87% of men in this cohort were drinkers, with of men with most males drinking to excess [ 38].
As a marker of excessive nitro-oxidative stress [ 33] a significantly higher NT positivity was shown in the diabetic myocardium which might have contributed to the observed induction of endogenous antioxidant systems (see thiorexodin-1, catalase or gluthatione-reductase gene expression levels) and to a remarkable heat shock response (increased HSP70a1 level).
We further investigated the data after taking into account the GGT level, a valid marker of excessive alcohol consumption [ 10, 23] The occurrence of DR was significantly higher in the ALDH2*2 allele carriers with a high GGT level at baseline than in the non-carriers with a high or low GGT level (Table 1, Figure 1b).
Markers with excessive numbers of double recombination events were eliminated as likely caused by sequencing error.
