Left ventricular heart failure was the best risk marker of events in this population, which was older and had a higher incidence of previous coronary disease than the average.
In 2008 advice from the Royal College of Obstetricians and Gynaecologists (Rai, 2008) echoed by the Human Fertilisation and Embryology Association (HFEA) stated that 'measurement of peripheral blood NK cell numbers or activity as a surrogate marker of events at the maternal-fetal interface is inappropriate' and is 'no better than tossing a coin' (Rai et al., 2005; HFEA, 2010).
Finds of steppe mammal fossils in Pleistocene-dated deposits in regions situated hundreds/thousands kilometers apart from their modern distributions are considered as markers of certain events in climate and landscape dynamics in North Eurasia during the late Pleistocene.
However, there is still little knowledge about the molecular markers of those events.
As argued earlier such measures are more appropriate as markers of sentinel events.
Other assays have utilized specific markers of key events in the process of apoptosis or necrotic cell death.
We constructed ROC curves with UAE, plasma copeptin levels, or both as markers of renal events (data not shown).
In the current study we attempted to compare parameters with opposite modes of action: comparing OP-1, which promotes anabolic, reparative processes, with factors that have been considered markers of degradative events (AgKS) or of predisposition to cartilage degeneration (HA).
If we adopt this rationale then we will always discard those legitimate somatic mutations that occur at polymorphic sites (it is ironic too that polymorphic sites are actually markers of mutation events sometime in the past).
In the evolution of a more ancient group of schistosomes, namely, avian schistosomes, multiple repeated changes of the definitive and intermediate hosts could also occur as well as generating of new molecular adaptations, and increasing the transposition activity of TEs may serve as markers of such events.
