Among these digestive symptoms, the principal marker of CF is PI.
This indicates that exhaled CO level is a marker of CF severity [ 107].
The clinical value of previous surrogate markers for CF, such as impedance, unipolar, and bipolar amplitudes, correlated with in vivo CF; however, due to a larger overlap, their clinical value is limited.
A retrospective study of the demographic, clinical, and laboratory markers for CF treatment at a CF referral center was performed during two decades: 2000 (DI, 1990 2000, n = 104 patients) and 2010 (DII, 2000 2010, n = 181 patients).
In this context, the aim of the present study was to evaluate and compare the demographic, clinical, and laboratory markers of patients with CF during the last two decades at a CF referral center.
Digestive symptoms are often the first clinical marker of classic CF and are reported in 95% of patients with classic CF. Because no change in prevalence was observed, this marker continues to be a target for first-line treatment of patients with CF. After initial treatment, the severity of symptoms and progression of lung disease decrease.
Larger and longer term studies should be conducted to evaluate the impact of vitamin D on clinical outcomes and other markers of health in CF patients.
Previous studies have described alternative laboratory markers to conventional bacteriological culture for the detection of Pseudomonas aeruginosa in CF patients.[ 4, 5] These markers have included serological testing of CF patients' sera for the presence of antibody to P. aeruginosa,[ 4] as well as molecular detection of DNA signature sequences of P. aeruginosa in CF patients [ 5].
In order to correlate the MLST sequence types with known molecular markers of S. agalactiae, the CF isolates as well as the colonizing strains from the urogenital tract of healthy patients were characterized by serotyping and surface protein determination.
We investigated the effects of CF on surrogate markers of cardiovascular health in low risk, healthy, middle-aged individuals without history, signs or symptoms of CVD.
