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Recently, SELDI has been successfully used to distinguish pancreatic, ovarian and prostate cancer patients from controls [ 9, 12, 13], and detect markers of bladder cancer in urine [ 14].
The paucity of urine markers of bladder cancer with high specificity and sensitivity warrants identification of non-invasive screening methods for early detection and prognosis of bladder cancer.
We found that there were 28 significant proteins that could be classified as a core network marker and 26, 4, 24, and 13 significant proteins that were specific network markers of bladder, colorectal, liver, and lung cancer, respectively.
Although to date, several markers of bladder cancer have been reported, such as nuclear matrix protein 22, hyaluronic acid, hyaluronidase and nuclear matrix proteins, these markers are ineffective in reducing the number of surveillance cystoscopies due to limited sensitivity and specificity [ 6].
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In this study, we examined whether UHRF1 can be a novel molecular marker of bladder cancer.
Thus, UHRF1 is much superior to p53 as a potential diagnostic marker of bladder cancer.
Overall, our data further strengthens the association of DEK with bladder cancer and as a potential marker of bladder cancer.
The decreased plasma levels of IL-27 compared to controls observed in our present study reinforces this predictive role as a marker of bladder cancer.
Standard urine cytology (Papanicolaou staining test) for the assessment of markers indicative of bladder cancer was performed.
To identify novel epigenetic markers of aggressive bladder cancer, we utilized a high-throughput DNA methylation bead-array in two distinct population-based series of incident bladder cancer (n = 73 and n = 264, respectively).
The few studies published on urine cell-free DNA alterations focus on their use as markers of early bladder cancer diagnosis [ 15, 17, 18].
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