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Understanding the response of EPA + DHA in blood to dietary intake of EPA + DHA would facilitate the use of blood measures as markers of adherence and enable the development of dietary recommendations.
Use of plasma HIV viral levels as surrogate markers of adherence is also difficult, but HAART users did have lower HIV viral levels than those not receiving HAART, suggesting that at least some subjects were compliant with HAART.
The need for better markers of adherence is underscored by the suboptimal results and relatively high false-positive rate for polypropylene applicator staining observed in this study and by the low sensitivity of this technique reported in a previous study [26].
Acyclovir suppression significantly but incompletely reduces symptomatic genital ulcers and HSV-2 shedding, so both are imperfect markers of adherence and drug exposure [ 27].
As markers of adherence to the intervention programme, the frequency of visiting the Health Portal, duration of stay on the Portal and frequency of contacts with professionals and personal coach will be registered.
The trial will evaluate the effectiveness of a brief self management intervention delivered in groups of established hemodialysis patients to improve biological markers of adherence and psychosocial functioning compared to standard care.
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The difference were confirmed by the urinary nitrogen excretion as a marker of adherence to HP or LP diet (13.8±3.3 and 11.8±3.3 g/day, p = 0.023).
We used issue of prescriptions as a marker of adherence with antidepressant therapy.
Time of HIVVL suppression can be a surrogate marker of adherence to HAART.
Plasma nevirapine concentration of >100 ng/ml was used as a marker of adherence (10 times the in vitro IC50 against HIV).
In addition, in the present study, the treatment discontinuation rate as a marker of adherence was adopted as the primary endpoint.
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