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Buildings, thrown up or torn down, are visible markers of action, Ms. Vatov noted.
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Additionally Error-related negativity (ERN, a marker of action monitoring and error processing) is recorded in an Erikson flanker task (ERN-FT [ 39]).
Progesterone receptor, IGF-I, and thioredoxin are all markers of oestrogen action in the uterus.
As an alternative, more suitable model, we explored pharmacodynamic markers of GH action in intact rabbits.
The authors suggest that these genes could be used as possible molecular markers of drug action in clinical trials.
Pharmacodynamic markers of drug action derived from easily accessible normal human tissue could assist clinical drug development.
In this study, in order to identify a more suitable, non-rodent animal model, pharmacodynamic markers of GH action were investigated in rabbits.
[62] The identification of better markers of TH action in different tissues is necessary to enable diagnosis of disorders with subtle HPT axis dysfunction and to guide treatment, especially in the context of central hypo- or hyper-thyroidism.
Of note, the observed changes in gene expression, when clustered, were predictive of response in all cases except one, whereas classical markers of estrogen action were not predictive [ 87].
In addition to the alteration of markers of androgenic action, the endocrine feedback loop (mainly the hypothalamic– pituitary target organ axis) could also be affected by BPA, showing no compensatory mechanisms of increased LH or FSH.
Our results suggest that low environmental levels of BPA in a large group of prospectively recruited fertile men is not associated with sperm quality but is weakly associated with markers of androgenic action.
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