Other types of genetic markers, including novel SNPs, may detect other genetic factors related to breed differentiation, especially those underlying adaptation and production traits, and should be investigated for use in conservation applications.
Indeed MM is characterised by repeated relapses, with increasing destruction at relapse [ 5]; sensitive markers of osteoclast destruction therefore may detect sub-clinical bone destruction and allow for early preventative intervention.
If confirmed in larger prospective studies, regular monitoring of patients with primary breast cancer by an optimal combination of circulating biochemical markers may allow detecting individuals with bone metastases at an early stage, potentially before detection with bone scintigraphy.
Similarly, SVR is a marker of hepatitis C progression that may detect changes in disease severity, even before they become symptomatic.
When diffusion barriers disappear, EMT markers may be detected in sera from cancer patients.
Moreover, tumor markers may be detected in sample matrices such as serum, plasma, whole blood, urine, and tissue.
This difference was previously attributed to the deeper coalescence for mtDNA compared to that for Y-chromosome lineages [ 38], however recent findings [ 39] indicates that these differences should be attributed to the fact that each uniparental markers may be detecting different gender-specific movements.
Analysis with PMF may detect associations for sources when marker constituents do not, or vice versa (Ito et al. 2004).
In comparison, molecular methods are highly sensitive and may detect DTCs based on their expression of tumor-specific markers.
