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Thus, not only the frequency of susceptibility variants but also the markers may affect the likelihood of detecting/replicating associations.
Recent studies [ 31– 33] suggested that the overexpression level of basal markers may affect the stratification of TNBC patients.
However, a bias present in the initial selection of markers may affect inferences about the larger population.
However, it is important to consider how the choice of markers may affect the estimation of breed proportion.
Even though histone acetylation and DNA methylation were closely correlated for both Tjp1 and Zic3, these two epigenetic markers may affect gene function to differing extents.
Currently, a common hypothesis is that a proportion of the causal variants tagged by these disease-associated markers may affect the abundance of a protein or the relative abundance of its different isoforms by altering transcription and/or splicing.
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In spite of being an easy and fast to achieve method, the introduction of a very active new transcriptional unit may affect expression levels of neighbouring genes [32] and the production of a foreign marker may affect virus replication in vivo.
Potier et al. recently reported that transplanted MSCs subjected to hypoxia in vivo exhibit a limited angiogenic factor secretion and persistent down-regulation of several osteoblastic markers, which may affect their bone-forming potential of these cells [ 9].
Microglia and astrocytes are two possible sources of pro-inflammatory markers that may affect the functioning of the BBB and thereby facilitate enhanced entry of tumor cells to the brain.
Functional magnetic resonance imaging (fMRI) responses to alcohol cues showed three of these genetic markers, which may affect TACR1 transcription and/or translation, were associated with brain regions in the mesocorticolimbic pathway [Blaine et al., 2013].
Further, previous studies have not accounted for possible time-dependent confounding of the association between MBD markers and death due to the effect of markers of MBD on treatments, which subsequently may affect MBD markers.
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