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Co-occurrence of these markers is more probable in SN+ subjects.
Conclusion: First-trimester screening for Down syndrome with nuchal translucency screening alone or with serum markers is more clinically effective and cost-effective than the current expanded AFP screen that is being used.
Through simulation studies, we show that testing all the markers is more powerful than testing only the most promising ones from the screening step, which was the method suggested by Van Steen et al. A comparison with a population-based approach shows that the approach achieves comparable power.
It needs fewer markers, is more robust to allelic heterogeneity, and can achieve higher mapping resolution than traditional linkage studies [37].
However, we propose that a criterion of ≥2 of 5 unstable markers is more accurate, as it enhanced the screening performance of the assay by identifying additional MSH6-deficient tumors without adding any false positives.
Regular monitoring of inflammatory markers is more reasonable for accurate clinical prediction.
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Yet while the marble markers are more refined, with their graceful shields and evenly sized and neatly spaced letters, the Fredericksburg headstones have a sturdy, hand-hewn look.
Molecular markers are more powerful tools for studying genetic diversity and relationships between genotypes.
The neurodegenerative (Fluoro jade B) and apoptotic (TUNEL) markers were more positive in CA1 and CA3 neurons.
We note that word-pair relation markers are more accurate than single-word markers, since their associated relations are usually definite and unique.
Pathophysiological alterations (e.g. functional and structural changes, release of neurotransmitters and inflammatory markers) are more pronounced in chronic headache and a link between headache frequency and chronification has been observed.
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Justyna Jupowicz-Kozak
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