The new marker is accepted as having predictive value if it is significantly associated with outcome in the multivariable model, after adjusting for established markers; if so, the marker is commonly referred to being an "independent" predictor of outcome.
Before a marker is accepted into a data set, the distribution of standardized intensities for each clone is examined across the complete panel of genotypes using K-means clustering.
Instead, a given topology is accepted by some markers and rejected by others, leading to multiple multicolour lines in mosaic heat maps.
NAA is accepted as a marker of neuronal density and viability.
NG2 is a cell surface proteoglycan widely expressed in both vasculogenic and angiogenic neovasculature, and is accepted as a marker for pericytes in microvessels [54].
Nodal involvement is accepted as the best single marker of prognosis in breast cancer.
Established tumour markers that were accepted as a measure of tumour response were also determined.
The minimum number of reads for an SNP marker to be accepted was five per allele; 181 distorted markers were removed.
At the completion of analysis, when all possible markers had been added to the map and the final marker order had been accepted, markers within each cluster were eliminated on the basis of high levels of missing data and then by lower Q values (a DArT quality measure).
Significant marker main effects were accepted with PBON-HOLM < 0.05.
