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Neural cell adhesion molecule (NCAM) expression is known to be associated with an aggressive biological behavior, increased metastatic capacity and expression of stem-cell markers in several tumor types.
In addition to its role in apoptosis suppression, Bcl-2 has been reported to be co-expressed with neuroendocrine markers in several tissues, leading to speculation that this oncoprotein may promote neuroendocrine differentiation.
Led by cell biologist Peter Pentchev of the National Institute of Neurological Disorders and Stroke and Danilo Tagle of the National Human Genome Research Institute (NHGRI), the team homed in on the gene by looking for inherited genetic markers in several afflicted families.
Using immuno-histochemistry or in situ hybridization, i.e. analytical methods that palliate kidney heterogeneity, authors reported increased expression of putative markers in several kidney pathologies [13] [17].
Increased levels of Skp2 and reduced levels of p27 are observed in many types of cancer, and these levels are used as independent prognostic markers in several cases [12].
Since the first report of the phage Cre/loxP system functioning in mammalian cells [29], both the Cre/loxP system and later the yeast Flp/FRT system have been shown to be effective in removing selectable markers in several types of mouse cells, including ES cells [30] [33].
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The phase angle α, a mathematical relation between R and Xc, has qualified as a prognostic marker in several severe diseases [ 1].
Overexpression of protein kinase CK2 is an unfavorable prognostic marker in several cancers.
Protein kinase CK2 is an unfavorable pronostic marker in several cancers and has consequently emerged as a relevant therapeutic target.
Immunoglobulin κ constant (IGKC) gene has recently been identified as a strong prognostic marker in several human solid tumors, including breast cancer.
Expression of Sca-1, a progenitor cell marker in several tissues, was detected in cells within the bronchiolar-like structures and colocalized with CCSP-expressing cells (Fig. 2E H).
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