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The feasibility of utilizing inflammatory markers in screening T2DM risk can be substantiated from numerous experimental, clinical and epidemiological observations demonstrating that the ability of inflammatory factors to predict the disease independently from established risk factors.
Other routine interventions such as ultrasound screening in the first trimester are effective in assessing gestational age accurately, in detecting twin pregnancies and, combined with serum screening markers, in screening for Down's syndrome (nuchal translucency scan) [ 28- 30].
Moreover, cell surface proteins are candidates for use as specific markers in screening [16].
One has to consider these effects when interpreting classic outcome surrogate markers in screening programmes.
Positive predictive value is one of the most important markers in screening programmes; high rates of false positives lead to large numbers of unnecessary investigations being undertaken.
The latter step is crucial to the inclusion of tests based on blood molecular markers in screening programs since early detection alone does not guarantee program efficacy or effectiveness when the biological basis of lesion detection is different [ 16, 17].
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Ergosterol may also serve as a marker in screening for strains that are suitable for bioethanol fermentation.
This PR-10 gene has also been used as a marker in screening for P. weirii resistance in Douglas-fir and could therefore be valuable in screening for PRR tolerance in avocado.
Notably, our study identified MMP-1 as the most upregulated marker gene for breast cancer, opening up the possibility, after follow-up validation studies, for its use as a putative predictive marker in screening for breast cancer.
Currently, CA19.9 is still the only widely used serologic tumor marker in screening and diagnosing PDAC; however, the sensitivity and specificity is not satisfactory, especially for early stage PDAC [ 6, 7].
This method is proved to be efficient in screening specific markers in microsatellite libraries.
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