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We discuss the advantages of the proposed eSPR approach for the development of highly selective sensor devices for the rapid and reliable detection of multiple molecular markers in complex samples.
This method greatly facilitates the quantification of chemical markers in complex matrixes with only a small amount of sample.
The ABfs of heterozygous informative markers in complex tumor samples depend on copy number and cellular composition of the sample.
Currently, Alus are repeat-masked in all studies pertaining to identification of predisposition markers in complex disorders.
DGRs therefore may be mobilized by transposons and might even co-opt the same integron system that appears to exchange resistance markers in complex transposons [ 13].
To date, proteomic analysis has proven to be the most powerful method for describing plant species and lines [ 10], and identification for proteins (especially protein markers) in complex mixtures.
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Several groups attempted to use NN to identify sets of markers involved in complex disease etiology [ 18- 23, 25, 25].
Modified versions of the CRIMAP 2.4 software [ 33], which can handle larger numbers of markers segregating in complex pedigrees, were utilized for the linkage analysis.
The discovery and implementation of genome-wide screening for single-nucleotide polymorphism (SNP) markers, even in complex polyploid crop species like B. napus, has advanced extremely rapidly in recent years since the introduction of ultrafast DNA sequencing technologies [ 7].
The modified CRI-MAP software version 2.4 [ 25] by Xuelu Liu (Monsanto), which can handle much larger numbers of markers segregating in complex pedigrees was utilized for the linkage analysis.
The less in numbers but more significant in terms of functions has made the nsSNPs an ideal marker type in complex trait association analysis.
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