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I do not think it is in the best interests of the Association to sponsor the markers given the potential for controversy.
The cases and controls were genotyped for 12 of the 30 exploratory set of SNPs, which were chosen using a pairwise tagging approach [31] to remove the redundancy among the genotyped markers, given the high level of LD between them.
These sequences provide a powerful tool for developing chromosome-specific markers given the high level of synteny among tetraploid and diploid cotton genomes.
To estimate the statistical significance of an ID value, we computed IDs between one million randomly generated markers given the same phenotype.
Other studies suggest that transferrin saturation is the preferred screening test, but it is important that each laboratory collects its reference values for iron biochemical markers, given the strong racial variability [ 25].
It infers founder ancestry probabilities at each marker by building a descent model and evaluating the probability of crossover between adjacent markers, given the genotypes and a transition penalty.
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Division of the samples into test and validation sets with which to test the prognostic usefulness of the markers gave the same Youden index values (see supporting Fig. S1 and legend for the data with CB1IR).
As expected, the combination of all three markers gave the best result with an AUC of 0.98.
MAS is widely used in gene pyramiding because the use of molecular markers gives the advantage of selecting the desired plants without extensive phenotyping.
In GWAS, summation of 2 p q α across all significant markers gives the total marked additive genetic variance under the assumption of linkage equilibrium between markers.
Combination of markers gave the best result for MCM5 and hTERT with a sensitivity of 76% and a specificity of 77% (Additional file 3).
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