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Since 2001, various molecular markers for thyroid tumors have been proposed on the basis of microarray analysis.
Genetic markers for thyroid cancers identified by microarray analysis have offered limited predictive accuracy so far because of the few classes of thyroid lesions usually taken into account.
Our analysis, covering the major subtypes of thyroid tissue, may be expected to enhance microarray data concerning thyroid tumors and lead to the definition of more reliable tissue-specific markers for thyroid lesions.
A number of other molecules have been described later on as malignancy markers for thyroid carcinoma.
We designed a nested case control study, which was affected little by bias, to validate blood markers for thyroid malignancy.
Thyroid transcription factor-1 (TTF-1) and thyroglobulin (TG) are important protein markers for thyroid gland function.
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SHBG is a sensitive marker for thyroid function.
We thus tested if ME may be used as an appropriate marker for thyroid hormone disrupting action.
In an early study, we have shown increased S100A4 expression in thyroid carcinoma specimens with advanced disease stage and indicated that it may be a useful prognostic marker for thyroid carcinoma (Zou et al, 2004).
Upregulation of ECM1 has been revealed in malignant compared to benign thyroid neoplasms and it has been proven to be useful as a diagnostic marker for thyroid malignancy in fine needle aspiration biopsies [ 27].
This study demonstrated that the levels of biomarkers of thyroid function/autoimmunity, particularly the presence of TPOAb, might be used as diagnostic markers for predicting thyroid cancer risk.
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