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FR- α and FR- β have been considered as cellular markers for targeted drug delivery because of their overexpression in solid tumors and in leukemia.
Together bioinformatics and biochemical data are being used to assemble the molecular markers for targeted grape improvement by classical breeding and genetic engineering.
We suggest the use of this and other species-specific markers for targeted surveillance of invasive species and prompt detection of the prospective incursions.
Here a sequence based polymorphic (SBP) marker technology for generating molecular markers for targeted genomic regions in Arabidopsis is described.
The SBP marker technology described here allowed the development of molecular markers for targeted genomic regions of Arabidopsis.
It should facilitate isolation of co-dominant molecular markers for targeted genomic regions of any animal or plant species, whose genomic sequences have been assembled.
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The most investigated example is the acute myeloid leukaemia (AML) CSCs, isolated more than a decade ago (Bonnet & Dick, 1997) leading to further identification of markers for targeting hematopoietic cancer stem/progenitor cells (Chan et al, 2009; Jin et al, 2006).
So, ICAM-1 could be identified as a marker for targeted drug delivery.
On the other hand, normal tissue distribution of the folate receptor is highly restricted, making it a useful marker for targeted drug delivery to tumors.
Similarly to demonstrate the application of sulfonylurea resistance cassette as a marker for targeted gene deletion in Z. tritici, sulfonylurea resistant strains transformed with pC-SUR-KU80-KO were isolated and designated HLS1002 Δku80 SurR R).
This makes CD44v6 a promising candidate marker for targeting of squamous cell carcinoma [22].
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