The FASSS therefore meets essential validation criteria for further assessment in patients with axial SpA in studies of treatment effect and as a surrogate marker for structural damage progression.
The aim of this study was to evaluate the periarticular mineralisation as detected by Digital X-ray Radiogrammetry (DXR) as surrogate marker for structural integrity during the course of rheumatoid arthritis (RA).
OII may therefore be considered a useful marker for structural changes, although very early degenerative changes (i.e., DJD grades 0 versus 1) may thus not be differentiated as demonstrated before [ 13].
In the present study, we confirmed the colocalization of L1-CAM and GAP-43 that is known as a marker for structural plasticity in the central nervous system (Benowitz et al., 1990; Masliah et al., 1991; Li et al., 1998).
However, DXR-BMD can be recommended as outcome measure and seems to be a valid surrogate marker for structural integrity caused by the similar pathogenetic mechanism as radiographic bone damage, because periarticular demineralization is still present, even if radiographic visible joint damage on X-rays apparently is arrested [ 26].
At least one of the markers, encoding for structural toxin protein RtxA, had previously already been identified as being associated with virulence.
12-lead electrocardiogram (ECG) – looking for possible markers of structural heart disease including left ventricular damage/dysfunction ○ For arrhythmias (atrial fibrillation, atrial flutter, heart block).
Despite this, many past workers interpreted the NNW-striking fabric as the result of only one regional contractional event, and used it as a marker for correlating structural events across the region.
This finding highlights the important role of sucrose metabolism in fiber morphogenesis and as a diagnostic marker for the structural properties that distinguish the superior Pima fiber phenotype.
Covalent modification of histones with methylation or acetylation will result in the chromatin structural change and could be used as markers for chromatin structure.
