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Indeed, the use of inflammatory markers for staging BD has been proposed [ 13, 14].
Therefore, additional accurate prognostic and predictive markers for staging must be identified as a complement to the TNM system for postoperative adjuvant therapy.
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Real time ultrasonography has become an integral part of the non-invasive evaluation of chronic liver disease in many clinical settings while the search for a non-invasive imaging marker for staging liver fibrosis or cirrhosis is inactive.
As clinical examination and biochemical markers are unreliable for staging hepatic fibrosis, the gold standard for establishing liver fibrosis is by histologic evaluation after liver biopsy.
The present study highlighted new potential markers for stage determination of T. b. rhodesiense patients.
IgM, MMP-9 and CXCL13 were the most accurate markers for stage determination (partial AUC 88%, 86% and 85%, respectively).
Sensitivity of EFHD1 methylation was also significantly higher than the protein markers for stage I CRC.
6 7 Identifying prognostic markers for stage I/II colon cancer remains a significant clinical problem.
Moreover, prognostic markers for stage III have been reported to have no significance for stage II cancers (Javle, 2010).
Therefore, there remains a need for alternative prognostic markers for stage-I gastric MALT lymphomas at diagnosis.
In these instances, the more reliable markers for stage 83 (sugar inflection point) and stage 87 (start of rapid flesh softening) should be used (Table 1).
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