However, correlative volume EM will reach it's full potential when markers for proteins of interest can be detected directly in the SEM forming a basis for understanding genetic and proteomic information in vivo.
This concentration can be used as a qualitative and even as a quantitative marker for protein adsorption.
An even more dramatic correlation is between low blood albumin (a marker for protein load) and infection.
Recently, another naturally secreted luciferase from the marine copepod Metridia longa has been characterized [26] and used as a marker for protein processing and ER stress.
At 100 days of age, both GFAP immunostaining, a marker for reactive gliosis, and ubiquitin immunostaining, a marker for protein aggregation, were significantly reduced in the treated mice, compared to the non-treated mice (Fig. 7B).
The cellular levels of 3-nitrotyrosine, a commonly-used marker for protein nitration and cellular oxidative stress, were also determined in tumor xenografts as a parameter for the intracellular ROS levels.
Within the present study we established a degradation assay based on earlier studies showing that susceptibility to endolysosomal proteolysis by antigen presenting cells (APC) serves as in vitro marker for protein immunogenicity [15], [16].
However, our replication of Harris et al's report confirm that rs1130233 can serve as a surrogate marker for protein levels in populations with high LD in this region, such as Caucasians.
