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The advent of MitoChip technology has allowed researchers to explore mtDNA for markers for primary cancers [ 1].
Following an in-depth PubMed search, 28 markers were selected that have been proposed as multivariate prognostic markers for primary prostate cancer.
They confirmed NANOG and OCT3/4 as sensitive and specific markers for primary seminoma and embryonal carcinoma and demonstrated that NANOG was a marker for metastatic GCTs.
Increasing circulating tumour DNA concentration and its decreasing integrity have potential as diagnostic markers for primary and metastatic breast cancer (68).
Epidemiologic studies have shown that exposure markers for primary products of fossil fuel combustion point to important causal sources behind associations of particle mass with cardiovascular outcomes (Delfino et al. 2005).
Since CK7 and TTF-1 are specific markers for primary lung cancer and CK20 and β-catenin for colorectal cancer, combined immunohistochemistry of these markers may be valuable in discriminating diagnosis.
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Napsin A is a relatively new marker for primary lung ADCs [44].
Double staining of anti-acetylated α-tubulin, marker for primary cilia, and anti-collectrin antibodies confirmed that collectrin expression was concentrated in primary cilia (Figure 2d).
In summary, this study shows that angptl4 is an accurate marker for primary ccRCC diagnosis but has no prognosis value for this RCC subtype.
Angptl4 mRNA expression was highly associated with ccRCC (p = 1.5 10−49, Chi square test) allowing to define its expression as a diagnosis marker for primary ccRCC.
GFP is used as a transduction marker for primary positive cell selection.
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