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No molecular markers for pathogenicity (e.g. PB2 E627K) were detected.
Several studies have focused on the determination of genetic markers for pathogenicity and virulence of WNV strains.
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cagA is one of the markers for a pathogenicity island of ca. 40 kilobases, which has been associated to more severe clinical outcomes [ 2]. vacA codes for another important virulence factor that induces vacuolization on eukaryotic cells in vitro, and different allelic variants in two regions of this gene has been described.
Isolates were also tested for several biochemical markers of pathogenicity (5 ).
Inositol fermentation has recently been proposed as a marker of pathogenicity for Cronobacter, based on the presence of the inositol monophosphatase gene (suhB) in pathogenic strains [ 32].
All H5N1 viruses isolated in Bangladesh had multiple basic amino acids at the cleavage site (CS) at positions 321 333 of the HA (H5 numbering), which is a marker for high pathogenicity in chickens.
VacA, present in all H. pylori strains, contains two variable parts relevant to virulence [ 4], whereas c agA, not present in every H. pylori strain, is a marker for a pathogenicity island (PAI) [ 5] associated with more severe clinical outcomes and an increased risk of developing gastric cancer and peptic ulcer [ 6].
The current circulating pandemic H1N1 does not contain the known molecular markers of pathogenicity and transmissibility [4], [9].
105 BALF is often used to understand respiratory disease mechanisms and to identify novel markers of pathogenicity.
Generic E. coli strains with the greatest acid resistance were assessed for pathogenicity markers and their survival in fermented meat compared with EHEC strains.
Thus, plaque size was not a marker of pathogenicity.
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