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We examined the expression of lineage markers for liver epithelial cells.
Even at low doses (1 2 mg/kg), there was a dose-dependent increase in markers for liver stasis and toxicity including serum total bilirubin (s-TB), serum alkaline phosphatase (s-ALP) and serum alanin aminotransferase (s-ALT).
Three genes, namely Myc, Glul, Oat, were transiently up- or down regulated during disease onset and may thus serve as early markers for liver cancer, which discriminate against the tumor state (Figure 2A).
Similarly, CLP-induced increases in surrogate markers for liver and kidney injury (AST, ALT and creatinine by 4.8-, 4.1-, and 2.9-fold, respectively) were completely blocked after treatment with BRL-44408 (Figs. 7C E).
Clinically, these enzymes are used as markers for liver injury.
Alterations in serum levels of hepatic transaminases (GPT and GOT) were used as markers for liver damage and disease.
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To screen miRNAs more efficiently as potential markers for liver-related diseases during the circulating miRNA profiling phase, we first generated seven pools of serum aliquots derived from individuals in the case and control groups.
PDRICG has been shown to be a good surrogate marker for liver function and hepatosplanchnic perfusion [7 11].
However, due to its unique hepatic elimination, PDRICG has been shown to be a good surrogate marker for liver function and hepatosplanchnic perfusion; therefore, the latter explanation seems more likely [10, 11, 20].
A novel label-free immunosensor based on hyperbranched polyester nanoparticles with nitrite groups (HBPE-NO2), which were synthesized through a simple one-step chemical reaction, was first developed for specific detection of α-fetoprotein (AFP), the tumor marker for liver cancer.
Another potential limitation of our study was the use of APRI as a surrogate marker for liver fibrosis.
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