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One of the main challenges in mammary cancer research is now to identify key proteins modulating tumor invasion, which can serve as early markers for invasive tumors as well as new drug targets.
Cluster 1 (orange) included ACSM1 and PGDH, two genes that were described as markers for invasive apocrine carcinomas (IACs), a subgroup of ER- breast cancer recently studied by Celis et al. [ 37, 38].
In fact, US guidelines recommend that such an approach (although they continue to call it empirical treatment) should be considered for critically ill patients with risk factors for invasive candidiasis and no other known cause of fever, based on clinical assessment of risk factors, serologic markers for invasive candidiasis and/or culture data from nonsterile sites [ 44] (Table 4).
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Aim: Aspergillus fumigatus produces the siderphore triacetylfusarinine C (TAFC) for iron acquisition and is essential for its virulence, therefore a specific marker for invasive aspergillosis.
This last observation underlines the importance of DCX as a marker for invasive NB cells.
It remains uncertain whether recurrent CIN is a surrogate marker for invasive cervical cancer.
HER2 (Human Epidermal Growth Factor Receptor 2) is an important marker for invasive breast cancer.
Thus, HPV load is a type-dependent risk marker for invasive carcinoma.
These observations emphasise the importance of monomeric Ln5- γ2 as a specific marker for invasive carcinoma.
Our results identify decreased expression of the PKD1 as a marker for invasive breast cancer.
Our results show that decreased PKD1 expression can serve as a marker for invasive and metastatic breast cancer.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com