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Our sequencing was not exhaustive therefore it is possible that these SNPs do not represent the functional variants but are acting as markers for functional polymorphisms that were not identified by our sequencing.
Among other reasons, the lack of suitable markers for functional traits has been one of the main limitations.
We selected 131 genes as potential TEC markers for functional screening using siRNA-mediated gene silencing (Fig. 2).
This study is helpful for understanding the genetic architecture of S. scrofa transcriptome and provides useful resource and markers for functional genomic research in future.
The questionnaires covered 18 health related domains, and included pre-clinical markers for functional decline, frailty and disability (Additional File 1: Table S1).
Moreover, these genic markers have proven to be advantageous over anonymous markers for functional genetic diversity estimation, construction of transcript map, marker-assisted selection, trait association analysis and comparative mapping as well as in evolutionary studies as anchor markers in plant species, including chickpea.
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Furthermore, ALP is an important marker for functional activity of cells such as cell proliferation.
Copeptin is a novel neuroendocrine peptide that is a strong and independent prognostic marker for functional outcome and death in patients with acute stroke3.
In conclusion, we defined CCR6 as a specific marker for functional antigen-specific Th17 cells during the immune response.
For instance, the expression of FOXP3 seems to be a more consistent marker for functional Treg in mice, than it is in humans [26] [28].
We used the measurement of plasma fructosamine as a surrogate marker for functional diabetes, using a threshold value of 2.6 mM/L [20].
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