Therefore, these markers have been proposed as pharmacodynamic markers for the extent of VEGFR inhibition.
Therefore, the MDA content reflects the extent of lipid peroxidation and is an indirect marker for the extent of hepatocyte injury in vivo [ 19].
Taken together, HOPX may be a marker for the extent of alveolar injury or a marker of the progression of repair, and failed regeneration.
In previous studies, we concluded that CT staging can be used as a decision-making marker for the extent of lymph node dissection [ 19].
The percentage of cells with low intensity of red fluorescence (pale cells) was used as a marker for the extent of lysosomal destabilisation (impairment of AO uptake).
Furthermore, the base deficit was shown to represent a highly sensitive marker for the extent of post-traumatic shock and mortality, both in adult and paediatric patients [ 109, 110].
Area under the curve (AUC) concentration measurements act as a marker for the extent of absorption, while peak concentration (Cmax) and time to Cmax (tmax) characterize the rate of absorption.
Seeking a potential explanation for why chaetocin-treated tumours were seemingly less vascular, and realising that phospho-VEGFR-1 level would be expected to represent a surrogate marker for the extent of VEGF activity in xenograft tumours, we examined tumour levels of both total and phospho-VEGFR-1 in homogenate of excised xenografts.
Thus, circulating levels of these byproducts may potentially be used as biochemical markers for assessing the extent of disease and prognosis, and for monitoring response to treatment [ 13].
Thus, measures from diffusion weighted imaging, such as fractional anisotropy, can be used to assess fibre integrity and have been postulated as sensitive markers for overall tumour extent ; however, research has so far been hampered by limitations in data analysis.
