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3 Melioidosis is notoriously difficult to cure despite appropriate antimicrobial therapy and has a case-fatality rate of up to 43%. 3 More than half of all melioidosis patients are bacteremic, and positive blood cultures for B. pseudomallei obtained at hospital admission and/or during hospitalization are strong prognostic markers for death.
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An assessment table was used as a surrogate marker for death and the animals euthanized according to approved criteria.
We have shown for the first time that tumoral CD105 is an independent predictive marker for death risk and unfavourable prognosis in patients with ccRCC after curative resection.
The aims of our study were to describe the clinical outcomes of V. vulnificus infected patients and identify an accurate and simple predictive marker for death.
Compared with the APACHE II score, the initial arterial blood pH level in V. vulnificus-infected patients was a more accurate predictive marker for death.
Patient survival differed significantly by pH level at hospital admission, and the initial pH level for patients was a more accurate predictive marker for death than was the APACHE II score.
Therefore, increased levels of the LC3-II and ATG7 proteins, biomarker for autophagy [36], and increased cleavage of caspase-3 and caspase-1, markers for cell death by apoptosis (Fig. 1A), prompted us to investigate whether the energetic stress in HDFs reduces cell viability.
We monitored activation of the executioner caspase 3 and measured lactate dehydrogenase (LDH) release as markers for cell death.
In conclusion, combined GSTM1*0/GSTA1*A genotypes might be considered as genetic markers for cardiovascular death risk in ESRD patients, which may permit targeting of preventive and early intervention.
Combined GSTM1*0/GSTA1*A genotypes might be considered as genetic markers for cardiovascular death risk in ESRD patients, which may permit targeting of preventive and early intervention.
Pharmacodynamic markers for cell death include measurement of active caspase 3/7, caspase cleaved cytokeratins and circulating DNA fragments (Ward et al, 2008).
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