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In addition several isoforms of CAs (namely, CA IX) also serve as biological markers for certain tumors, and therefore they have the potential for useful applications in the treatment of cancer.
There are several clinical examples of autoantibodies against systemically expressed autoantigens that are highly sensitive and specific diagnostic markers for certain organ-specific autoimmune diseases.
1/ The work presented in this paper, at best, shows the proposed method fails to find prognostic markers for certain lung carcinoma.
Since all keratins have an exquisite cell type- and differentiation stage-specific regulation and expression pattern, it might well be that upon future research further keratins will be introduced as markers for certain diagnostic questions in pathology to widen and to refine the diagnostic potential of keratins.
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Recent studies showed morphology of polymorphous organelle mitochondria can be used as a relevant biological marker for certain diseases.
Moreover, changes in the HLZ concentration in serum or urine is used as a diagnostic marker for certain diseases [10].
GFP expression can be used as a sensitive marker for certain tissue or cell types.
There is an increasing body of evidence demonstrating that overexpression of TF is a characteristic marker for certain neoplasms.
For example, TNC has been proposed also as a potential diagnostic marker for certain cancers such as gliomas and bladder cancer because of its correlation with poor patient survival (Herold-Mende et al, 2002; Brunner et al, 2004).
Although maternal serum alpha-fetoprotein (MSAFP) is a highly sensitive marker for certain congenital malformations such as open neural tube and ventral wall defects, its usefulness as a screening test for fetal hydrocephalus is uncertain.
Although miR-146b is regarded as a relevant diagnostic marker for certain types of cancer, potential roles in adipogenesis and hypertrophy of adipose tissue have not yet been demonstrated.
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