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We show that miR-9/9* are markers for aggressive tumors, being expressed specifically in the basal-like tumors.
The value of these metabolites as plasma markers for aggressive PCa however needs to be confirmed in further studies.
This study was made with the hypothesis that potential novel markers for aggressive PCa could be discovered by finding factors markedly up-regulated in bone metastases and then examine if the same factors are also increased in blood samples and in primary tumors from patients with metastatic disease.
Notably, our earlier report in thyroid cancers demonstrated a strong association between nuclear accumulation of Ep-ICD and a reduced membranous EpEx localization as well as shortened overall survival, suggesting the potential application of the relative subcellular expression of Ep-ICD versus EpEx as prognostic markers for aggressive thyroid cancers.
There are no well-known tumor markers for aggressive behavior.
It would follow that the BRCA1 and BRCA2 mutations are therefore prognostic markers for aggressive PRCA.
Similar(45)
These patients have a 4-fold lower survival than those remaining free of VTE, implying VTE is a surrogate marker for aggressive cancer.
Yet another study, done at the national level, similarly found that "riding with a firearm in the vehicle appears to be a marker for aggressive and dangerous driver behavior".
Together, these observations suggest that increased expression of pro-inflammatory genes such as COX2, IL-8 and CCL2 may characterize the VDRff variant in breast cancer cells as a possible clinical marker for aggressive tumors.
This observation supports the hypothesis that excessive AURKB expression is a marker for aggressive tumour biology.
There have been previous functional studies suggesting FN as a candidate marker for aggressive RCC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com