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Most prior work on tumor markers focused on their possible diagnostic utility.
Early attempts to discover breast cancer DNA methylation markers focused on a shortlist of candidate genes and were highly biased towards DNA hypermethylation of CG islands in tumor suppressor genes.
Other meta-analyses on effusion markers focused on differentiating benign from malignant diseases in general, and as such are not directly comparable with our review as our focus was to quantify the diagnostic accuracy of these markers for discriminating mesothelioma from non-mesothelioma (Liang et al, 2008; Shi et al, 2008).
One relatively recent study looking at laboratory markers focused on platelet and neutrophil count [ 8], and suggested that in an age of improved recognition and management of disease, markers of endothelial dysfunction were more useful than clinical markers of poor perfusion, the former representing pathophysiology not amenable to any specific treatment.
GP9 highlighted the difference in the exposure between adults and paediatric medicine in training: " 'Some GPs will come in [to general practice] with no paediatric experience at all, whilst essentially virtually no doctor will come into general practice without ever working with adult populations.' (GP9)" Clearly there seems to be a role for developing markers focused on training.
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The quantitative variation observed in the accumulation of these bioactive markers focuses on the importance of standardization and quality evaluation of medicinal formulations based on P. kurroa.
The exonic content of the HumanExome chip consists of more than 250,000 markers focusing on exonic regions.
We examined the correlation between the presence of HLA-B*35 and the expression of ER stress markers, focusing on the genes previously shown to be elevated in lcSSc-PAH PBMCs [ 15].
The traditional biostatistical approach to evaluating tests, models and markers focuses on accuracy, evaluating calibration and discrimination using metrics such as sensitivity, specificity or area-under-the-curve (AUC).
The AOSI [ 10] is a validated clinical measure of infant risk markers, focusing on precursors of impairments present in the ASD phenotype, including response to name, eye contact, social reciprocity, and imitation.
In the current study, surgical samples and matched clinical data were used to identify a prognostic marker, focusing on the genomic alterations of hepatic carcinogenesis.
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