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Such heterogeneity is reflected by the wide range of sub-classifications (diagnostic markers) and risk-stratifications (prognostic markers) existing for many cancer types, as well as by the increasing number of molecules able to forecast the response of patients to personalized therapies (predictive markers) [15].
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Existing for-profit schools could remain open.
For catfish, the sequence-tagged markers existing on the linkage map are the BAC-derived microsatellite markers [ 48].
Urine insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2) are new biomarkers for AKI and perform better than existing markers for predicting the development of moderate or severe AKI (KDIGO stage 2 or 3) within 12 hours of sample collection.
Segregation data for a total of 1150 DArT markers was recorded, of which 942 could be associated with one or more markers in the existing LGs for the F2 family with a LOD ≥3.
Although many 'tumor markers' are widely used in monitoring cancer patients during therapeutic interventions, lack of sensitivity and specificity preclude the use of most existing markers for the early detection of malignancy [ 35].
These new microsatellite loci will be a valuable addition to existing markers for detailed landscape and population genetic analyses of D. tenebrosus across its range.
DNA from this resource will be made available to research groups seeking to place additional public domain markers on the existing framework for map refinement.
This may be challenging: not all subpopulations may be experimentally separated (e.g., because of a lack of unique membrane markers or a lack of antibodies for existing markers) and separation may itself affect abundance of the RNA transcript of interest (either directly or by eliminating necessary stimulus from surrounding cells).
Although much of the additional information from expression profiling of primary tumours is consistent with that for existing markers, there have been some conflicting results; for example, some women found to be ERBB2 positive by immunohistochemistry were classified in the luminal cluster and not the ErbB2 group [ 4].
Application of ILIR can be useful during marker selection and design of new marker panels, as well as being highly relevant for existing marker sets as a way to properly evaluate the effects of linkage on a case-by-case basis.
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