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In addition, 14 markers are listed that were part of a sequence of significant markers defining a QTLR, although they did not reach significance for Z or CS.
This allowed for more exacting definition of the boundaries, based on the outermost heterochromatin and euchromatin markers, defining a transition zone with an average size of 78 kb (range: ~15 to 226 kb).
Interestingly, expression of Snail was positively correlated to tumour grade (P=0.003) and to expression of the proliferation marker Ki67 (P=0.024), implying that nuclear Snail expression is associated with markers defining a more aggressive disease in breast cancer (Table 2).
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While a minimal set of markers defining an MSC has been agreed upon [ 12], expression of these markers is clearly heterogeneous both in vivo and in vitro and does not currently allow their prospective purification.
These markers defined a potentially shared interval of 361 Kbp containing three genes (3' end of PEX14, CASZ1, SRG [not currently annotated by RefSeq]).
As expected, those markers define a strongly associated haplotype in our population (P<0.000001 for haplotype H2, based on 1,000,000 permutations, Supplementary Table S4).
These three markers define a 7.2 cM interval on the GPMx GBS map.
Synteny relationships identified by two or more consecutive conserved markers defined a conserved segment (CS) while a single marker identified a singleton [ 35][ 36].
These two markers defined a 410-kb region in sorghum in which 40 genes had been annotated (www.phytozome.net; Sbi1.4 gene set).
These markers define a region on chromosome 18p previously shown to undergo LOH in invasive ductal breast carcinomas as well as non-small cell lung carcinomas and glioblastomas [ 1, 2].
We demonstrate that the expression patterns of BRCA1, pRb, p16, PTEN and p53 are highly correlated with one another, and that these markers define a subgroup of TNBCs associated with genetic or epigenetic defects in the BRCA1 gene.
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