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The distinct regulation of these markers could reflect differences of in vitro culture conditions versus in vivo expression.
Second, the mutually incompatible groupings proposed by these markers could reflect lineage sorting, as illustrated in previous studies on seaweeds[ 90].
While this increase in epithelial cell markers could reflect an increase in the number of epithelial cells, it might also reflect a change in the size of these cells, or a change in the patterns of genes expressed in these cells.
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Studies also demonstrate the level of fecal S100A12 decreases as anti-inflammation treatment, suggesting that this marker could reflect the response of drug treatment.
The reason for this finding is at present not clear, but underscores that it is unlikely that one marker could reflect all inflammatory pathways involved in complex disorders like type 2 diabetes and its CV complications.
Bimodal expression and broad expression of antigen markers in ALL could reflect two different biological phenomena.
Therefore, the limited use of these markers could merely reflect activation and thus lead to a false assessment of elevated Treg numbers.
The 117 markers with skewed segregation that were linked by at least 5 cM to markers that weren't distorted could reflect residual levels of heterozygosity in the lines (when scored with dominant markers), due to either natural or artificial selection, sampling bias due to lower numbers of markers in these regions or mis-scoring of the markers.
The absence of the CD44 surface marker was unexpected but could reflect the true phenotype of the cancer stem cell, the CD24low/- CD44+ profile reflecting the phenotype of progenitor cells.
Inhibition of Nodal signaling induces the extension of the apical domain marker Pf-fz5/8 that could reflect an anteriorization of the treated embryo, the first demonstration of this role in any ambulacrarian.
Thus, these inversions of marker order or positioning could reflect real genetic events such as small chromosome rearrangements or, as they occur mostly after gaps, they could also be caused by statistical uncertainty due to many weak linkages contributing to the adjustment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com