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Differences in the marker systems and extent of the genome coverage (414 mapped microsatellite vs. 149 RAPD markers) could explain the resolution differences between studies.
Similarly, the two DArT markers could explain 10.0% and 6.6% of phenotypic variation for the mean values of 2011 and 2012.
We suggest that pallidal dopamine depletion is related to tremor, while other pathophysiological markers could explain a more benign disease course.
The discrepancies between population structures, methods of analysis, and density and informativity of markers could explain the differences between the results of Tribout et al. [ 38] and our study.
The possibility that recombination hotspots are encoded by multiple histone modification signals, and potentially repressive or bivalent markers, could explain several intriguing and currently unresolved observations regarding recombination hotspots in mammalian genomes.
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Our results also showed that for all traits, except IB, fitting all markers simultaneously could explain most or all the trait heritability.
These studies are confirmed by our exploratory results with risk markers and could explain the inverse relation between dietary menaquinones and type 2 diabetes.
Further investigations should be carried out to better characterise the genetic profile and the pharmacological markers, which could explain the unfavourable responsiveness and prognosis of mucinous colorectal tumours.
Ingenuity Pathway Analysis of deregulated genes revealed that epigenetic-mediated Trim28 upregulation in MF mice could lead to the upregulation of several markers that could explain this phenotype such as Igf- 1 (insulin growth factor-1) and c- Met proto-oncogene.
In contrast to the C6 fragment, the C9 does not include the promoting gene/genes around the D5Mit317 marker, which could explain why the C9 congenic mice are more protected from disease development.
We looked next at whether the swollen joint count as a marker of inflammation could explain the difference between cases and controls, assuming that the controls had no inflamed joints.
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