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While SSR markers are robust and reliable for genetic analysis within a species, their transferability between species and genera is more limited than for other marker types.
These reports are encouraging in that they provide positive evidence that peripheral markers are robust and are able to produce some findings that are comparable to those from postmortem studies, thus lending support to the use of peripheral blood samples as an advantageous alternative in the quest for the biological markers of brain-based disorders.
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The functional markers were robust to perturbations in AKT and TOR with differing effects on ERK activity and slight decreases in expression levels upon AKT or TOR knock-out (Fig. 8, lanes 4 and 5).
By contrast, the CAPS and indel markers were robust and reproducible.
Chuang et al. (2007) demonstrated that subnetwork markers are more robust, i.e. their results tend to provide more reproducible results across different cohorts of patients.
There were two markers that were predictive of aggressiveness and three markers of lethal outcome when measured in high, but not in low-Gleason areas, indicating that these markers are not robust to sampling error.
Recently, our group and others demonstrated that lineage-restricted transcription factors such as OCT4 and NANOG are robust markers for the diagnosis of germ cell tumors, including those in the central nervous system[26] [29].
Nevertheless SNPs are robust markers in defining MTBC lineages.
As demonstrated in previous studies, these ISGs are robust markers of IFN-I upregulation associated with SLE [ 3- 5].
This confirms that miR-205 and miR-93 are robust markers of good and poor prognosis, respectively.
Admission GCS score and Modified Fisher Scale are robust markers of the severity of the initial bleeding event, and both predicted in-hospital mortality.
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