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GS cannot currently account for this scenario; thus, informative markers are lost.
Expression patterns of epidermal progeny markers are lost in a ventral-to-dorsal, anterior-to-posterior manner.
During these cellular changes, the actin molecular architecture is disrupted and protein complexes like the cadherin catenin complex and epithelial markers are lost [ 47].
However, with continued passaging of ASCs, these APC-associated markers are lost, effectively mitigating the immune response until it has been eliminated.
However, in maize, after a centromere has been epigenetically deactivated (when CENH3 and other kinetochore markers are lost), the same region can regain activity, hinting that centromere elements present a particularly permissive environment for centromere formation [ 51].
In the course of DNA elimination all repressive markers are lost, probably by selective degradation of the banded regions of the polytene chromosomes, while the 'active' markers stay associated with MDSs and are still found in the mature differentiated macronucleus.
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When a dominant-negative form of lhx1 is expressed in the anterior kidney field, expression of proximal tubule markers is lost [30].
Only CD44+ cells expressed the pluripotency genes POU5F1, NANOG and SOX2 [27], [28], [29], [29], while these markers were lost in CD44− cells, suggesting that EMT may be involved in maintaining stemness.
When grown at low (clonal) density and switched into conditions that support differentiation, the precursor markers were lost and the cells acquired morphologies and antigen expression patterns found in neurons, astrocytes, and oligodendrocytes (Figure 1G H; Table 1).
In THAL, multiple astrocytic markers were lost consistent with glial cell loss.
After differentiation into glial lineage, neuronal markers were lost, while cells that differentiated into neuronal lineage, lost glial markers [ 5, 6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com